UTP14C small subunit processome componentGenealiases: 2700066J21Rik · KIAA0266 · UTP14B
Q-omics provides the consensus-scored UTP14C profile across patient tissues and cancer cell-line models. UTP14C expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, UTP14C is differentially expressed in 10, with the highest sampling consensus in KICH. Additionally, UTP14C RNA expression shows 21,075 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRC, KICH, and THYM as cancer lineages where UTP14C shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for UTP14C — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes UTP14C survival associations across molecular data types. UTP14C RNA expression shows survival associations in the most cancer types (24), followed by mutation status (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible UTP14C RNA expression–survival associations across cancer types. High UTP14C expression shows unfavorable associations in CESC, HNSC, OV and BLCA, but favorable associations in KIRC and UCS. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for UTP14C RNA expression.
This table summarizes UTP14C tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 1. The strongest signals are observed in THCA for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for UTP14C. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. UTP14C shows lower tumor expression in KICH, THCA, LUSC and KIRP and higher tumor expression in STAD and CHOL. The KICH box plot shows higher UTP14C RNA expression in normal versus tumor tissue (log2 FC = −1.597, t-test p < 0.001).
This table shows molecular features associated with UTP14C in patient tissues and cancer cell lines. In patient samples, UTP14C shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, UTP14C RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Leukemia.
