UTP14C

Across TCGA pan-cancer cohorts, UTP14C Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated UTP14C data layer compared with 24 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher UTP14C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UTP14C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UVM, OV, and STAD are the cancer types where UTP14C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.213	0.718	.002	27	view →
OV	DFS	Median	II,III,IV	0.209	0.543	<.001	18	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
ESCA	OS	Median	All	0.329	0.710	.002	12	view →
BRCA	OS	Median	All	0.410	0.924	<.001	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
UCEC	DFS	Median	All	0.959	0.621	.024	6	view →
COAD	OS	Median	III,IV	0.163	0.791	.004	6	view →
SKCM	OS	Median	IV	0.179	0.755	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

UTP14C–UVM (OS)

Open the UVM breakdown →