ubiquitin specific peptidase 12Genealiases: UBH1 · USP12L1
Q-omics provides the consensus-scored USP12 profile across patient tissues and cancer cell-line models. USP12 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, USP12 is differentially expressed in 12, with the highest sampling consensus in HNSC. Additionally, USP12 RNA expression shows 21,232 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, HNSC, and ACC as cancer lineages where USP12 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for USP12 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes USP12 survival associations across molecular data types. USP12 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (1) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible USP12 RNA expression–survival associations across cancer types. High USP12 expression shows unfavorable associations in CESC, UVM, ACC and KICH, but favorable associations in KIRC and SKCM. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for USP12 RNA expression.
This table summarizes USP12 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 4. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for USP12. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. USP12 shows lower tumor expression in LUSC, LUAD, BLCA, KIRP and THCA and higher tumor expression in HNSC. The HNSC box plot shows higher USP12 RNA expression in tumor versus normal tissue (log2 FC = +0.868, t-test p < 0.001).
This table shows molecular features associated with USP12 in patient tissues and cancer cell lines. In patient samples, USP12 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, USP12 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and UPPER_AERODIGESTIVE_TRACT.
