USP12

Across TCGA patient cohorts, USP12 protein abundance is significantly associated with the RNA expression of many other genes, with 5,272 significant associations in total. GBM shows the largest number of these associations.

The most reproducible USP12-associated genes across cancer lineages are ASPA, SEPTIN4, and KHDRBS2. Each is linked with USP12 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP12-to-partner and partner-to-USP12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP12 versus ASPA in GBM, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP12→partner) and Y-score (partner→USP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ASPA →	+1.357	+0.506	<.001	.001	3	3
GBM	SEPTIN4 →	+0.969	+0.404	<.001	<.001	3	3
GBM	KHDRBS2 →	+0.875	+0.401	<.001	<.001	3	3
LSCC	CLIC5 →	+0.942	+0.234	.001	<.001	3	3
LUAD	HROB →	-0.645	-0.251	.003	<.001	3	3
GBM	MGAT3 →	+0.857	+0.469	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,272 associations by consensus.

USP12 vs ASPA — GBM

Explore this scatter interactively →