USP12

Across TCGA patient cohorts, USP12 mutation is significantly associated with the RNA expression of many other genes, with 2,144 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP12-associated genes across cancer lineages are RNA5SP413, RPL23AP84, and MIR6858. Each is linked with USP12 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP12-to-partner and partner-to-USP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by USP12-low versus USP12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP12→partner) and Y-score (partner→USP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP413 →	+0.858	+1.692	<.001	.004	3	2
UCEC	RPL23AP84 →	+0.050	+2.379	<.001	.008	3	2
BRCA	MIR6858 →	+0.398	+4.646	<.001	.008	3	1
LGG	RNU6-280P →	+0.283	+7.977	<.001	.007	3	1
LGG	DLGAP5P1 →	+0.074	+7.977	<.001	.007	3	1
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,144 associations by consensus.

RNA5SP413 by USP12 expression — UCEC

Explore this box plot interactively →