USP12

Across TCGA pan-cancer cohorts, USP12 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated USP12 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher USP12 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated USP12 expression acts as an unfavorable survival marker.

HNSC, PDAC, and CCRCC are the cancer types where USP12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.469	0.784	.018	6	view →
PDAC	DFS	Median	All	0.228	0.467	.038	4	view →
CCRCC	DFS	Tertile	All	0.636	0.861	.028	4	view →
LSCC	DFS	Quartile	II,III,IV	0.766	1.000	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

USP12–HNSC (OS)

Open the HNSC breakdown →