USH1 protein network component harmonin binding protein 1Genealiases: AIEBP · MCC2
Q-omics provides the consensus-scored USHBP1 profile across patient tissues and cancer cell-line models. USHBP1 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, USHBP1 is differentially expressed in 15, with the highest sampling consensus in KICH. Additionally, USHBP1 protein abundance shows 35,362 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRP, KICH, and GBM as cancer lineages where USHBP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for USHBP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes USHBP1 survival associations across molecular data types. USHBP1 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (3) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible USHBP1 RNA expression–survival associations across cancer types. High USHBP1 expression shows unfavorable associations in KIRP and MESO, but favorable associations in KIRC, HNSC, UCEC and LIHC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify KIRP as the clearest survival context for USHBP1 RNA expression.
This table summarizes USHBP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 10. The strongest signals are observed in KIRP for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for USHBP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. USHBP1 shows lower tumor expression in KICH, KIRP, LUAD, LUSC and BLCA and higher tumor expression in LIHC. The KICH box plot shows higher USHBP1 RNA expression in normal versus tumor tissue (log2 FC = −1.612, t-test p < 0.001).
This table shows molecular features associated with USHBP1 in patient tissues and cancer cell lines. In patient samples, USHBP1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, USHBP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in SKIN and LARGE_INTESTINE.
