USHBP1

Across TCGA pan-cancer cohorts, USHBP1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of USHBP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where USHBP1 RNA is repressed in tumor relative to normal tissue. In most cancer types USHBP1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and LUAD are the cancer types where USHBP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USHBP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.612	<.001	11	view →
KIRP	Male	All	−1.583	<.001	11	view →
LUAD	Female	III,IV	−2.064	<.001	9	view →
LUSC	Female	II,III,IV	−2.352	<.001	8	view →
BLCA	All	All	−0.632	<.001	8	view →
LIHC	Female	All	+0.703	<.001	7	view →
BRCA	All	II,III,IV	−1.455	<.001	6	view →
THCA	Male	IV	−0.893	<.001	5	view →
KIRC	All	All	+0.357	<.001	3	view →
COAD	All	II,III,IV	−0.215	.007	3	view →
UCEC	All	All	−1.028	.001	2	view →
PRAD	All	All	−0.209	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

USHBP1–KICH

Open the KICH breakdown →