URI1 prefoldin like chaperoneGenealiases: C19orf2 · NNX3 · PPP1R19 · RMP · URI
Q-omics provides the consensus-scored URI1 profile across patient tissues and cancer cell-line models. URI1 expression is associated with patient survival in 29 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, URI1 is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, URI1 RNA expression shows 20,253 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, HNSC, and ACC as cancer lineages where URI1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for URI1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes URI1 survival associations across molecular data types. URI1 RNA expression shows survival associations in the most cancer types (29), followed by mutation status (7) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible URI1 RNA expression–survival associations across cancer types. High URI1 expression shows unfavorable associations in OV, ACC, UCEC, KIRP and LIHC, but favorable associations in KIRC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for URI1 RNA expression.
This table summarizes URI1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 5. The strongest signals are observed in HNSC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for URI1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. URI1 shows lower tumor expression in THCA and higher tumor expression in HNSC, COAD, LUSC, LUAD and LIHC. The HNSC box plot shows higher URI1 RNA expression in tumor versus normal tissue (log2 FC = +0.576, t-test p < 0.001).
This table shows molecular features associated with URI1 in patient tissues and cancer cell lines. In patient samples, URI1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, URI1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Lymphoma and BLOOD_Leukemia.
