URI1

Across TCGA cell cohorts, URI1 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible URI1-associated genes across cancer lineages are FCN2, OR5T1, and ASB17. Each is linked with URI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both URI1-to-partner and partner-to-URI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by URI1-low versus URI1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URI1→partner) and Y-score (partner→URI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FCN2 →	+0.022	+3.415	<.001	.001	3	2
SKIN	OR5T1 →	+0.014	+4.415	<.001	.007	3	1
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
LARGE_INTESTINE	RSPH4A →	+0.304	+3.452	<.001	.002	3	1
LARGE_INTESTINE	ARL6 →	+0.638	+3.064	<.001	.009	3	1
LARGE_INTESTINE	GALR3 →	+0.126	+3.865	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

FCN2 by URI1 expression — LARGE_INTESTINE

Explore this box plot interactively →