URI1

Across TCGA pan-cancer cohorts, URI1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated URI1 data layer compared with 29 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher URI1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated URI1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where URI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.890	0.656	.003	29	view →
LUAD	OS	Quartile	All	0.769	0.958	.012	10	view →
LSCC	OS	Median	All	0.793	1.000	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

URI1–PDAC (DFS)

Open the PDAC breakdown →