URI1

Across TCGA patient cohorts, URI1 mutation is significantly associated with the RNA expression of many other genes, with 3,790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible URI1-associated genes across cancer lineages are TRAJ21, RNU6-1127P, and TRGV1. Each is linked with URI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both URI1-to-partner and partner-to-URI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ21 grouped by URI1-low versus URI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URI1→partner) and Y-score (partner→URI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ21 →	+0.282	+1.828	.008	.003	3	3
COAD	RNU6-1127P →	+0.332	+4.721	<.001	<.001	3	2
COAD	TRGV1 →	+0.162	+2.774	<.001	.008	3	2
COAD	LINC02521 →	+0.139	+2.567	.003	.009	3	2
COAD	BANF1P1 →	+0.367	+2.567	.003	.009	3	2
COAD	LINC01727 →	+0.106	+2.965	.006	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,790 associations by consensus.

TRAJ21 by URI1 expression — UCEC

Explore this box plot interactively →