URI1

Across TCGA patient cohorts, URI1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible URI1-associated genes across cancer lineages are FoxM1, Ku80, and mTOR_pS2448. Each is linked with URI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both URI1-to-partner and partner-to-URI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by URI1-low versus URI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URI1→partner) and Y-score (partner→URI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.245	+1.925	.008	.005	3	2
UCEC	Ku80 →	+0.208	+1.598	.014	.011	3	2
UCEC	mTOR_pS2448 →	-0.137	-1.658	.010	.021	3	2
UCEC	CDK1 →	+0.108	+2.183	.048	.033	3	2
UCEC	eIF4G →	+0.261	+2.115	.019	.016	3	1
UCEC	FOXO3a_pS318_S321 →	-0.093	-2.212	.039	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

FoxM1 by URI1 expression — UCEC

Explore this box plot interactively →