ubiquinol-cytochrome c reductase, complex III subunit XIGenealiases: 0710008D09Rik · QCR10 · UQCR
Q-omics provides the consensus-scored UQCR11 profile across patient tissues and cancer cell-line models. UQCR11 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, UQCR11 is differentially expressed in 5, with the highest sampling consensus in LIHC. Additionally, UQCR11 RNA expression shows 20,072 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight UVM, LIHC, and THYM as cancer lineages where UQCR11 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for UQCR11 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes UQCR11 survival associations across molecular data types. UQCR11 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (1) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible UQCR11 RNA expression–survival associations across cancer types. High UQCR11 expression shows unfavorable associations in UVM, ACC, UCS and SKCM, but favorable associations in PAAD and LUSC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for UQCR11 RNA expression.
This table summarizes UQCR11 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5, while mass-spec protein shows differences in 1. The strongest signals are observed in LIHC for RNA and PDAC for protein.
This table ranks reproducible tumor–normal expression differences for UQCR11. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. UQCR11 shows higher tumor expression in LIHC, BRCA, CHOL, KIRP and ESCA. The LIHC box plot shows higher UQCR11 RNA expression in tumor versus normal tissue (log2 FC = +0.695, t-test p < 0.001).
This table shows molecular features associated with UQCR11 in patient tissues and cancer cell lines. In patient samples, UQCR11 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, UQCR11 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and SKIN.
