UDP-N-acetylglucosamine pyrophosphorylase 1 like 1Genealiases: []
Q-omics provides the consensus-scored UAP1L1 profile across patient tissues and cancer cell-line models. UAP1L1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, UAP1L1 is differentially expressed in 15, with the highest sampling consensus in HNSC. Additionally, UAP1L1 RNA expression shows 16,067 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight MESO, HNSC, and THYM as cancer lineages where UAP1L1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for UAP1L1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes UAP1L1 survival associations across molecular data types. UAP1L1 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (6) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible UAP1L1 RNA expression–survival associations across cancer types. High UAP1L1 expression shows unfavorable associations in MESO, ACC, UCS, BLCA and LIHC, but favorable associations in PAAD. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for UAP1L1 RNA expression.
This table summarizes UAP1L1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 5. The strongest signals are observed in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for UAP1L1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. UAP1L1 shows lower tumor expression in THCA and higher tumor expression in HNSC, STAD, COAD, KICH and UCEC. The HNSC box plot shows higher UAP1L1 RNA expression in tumor versus normal tissue (log2 FC = +1.648, t-test p < 0.001).
This table shows molecular features associated with UAP1L1 in patient tissues and cancer cell lines. In patient samples, UAP1L1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, UAP1L1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and SKIN.
