Across TCGA pan-cancer cohorts, UAP1L1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UAP1L1 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher UAP1L1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UAP1L1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

COAD, GBM, and CCRCC are the cancer types where UAP1L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	All	0.856	1.000	.012	54	view →
GBM	OS	Tertile	All	0.232	0.522	.006	18	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	16	view →
LUAD	OS	Median	III,IV	0.750	0.997	.031	6	view →
HNSC	DFS	Median	IV	1.000	0.413	.033	2	view →
LSCC	OS	Median	All	0.777	1.000	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: UAP1L1 tumor-vs-normal RNA expression · all UAP1L1 data types