Q-omics provides the consensus-scored TUBB8 profile across patient tissues and cancer cell-line models. TUBB8 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, TUBB8 is differentially expressed in 13, with the highest sampling consensus in LUAD. Additionally, TUBB8 RNA expression shows 16,082 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight ACC, LUAD, and THYM as cancer lineages where TUBB8 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TUBB8 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TUBB8 survival associations across molecular data types. TUBB8 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (5) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TUBB8 RNA expression–survival associations across cancer types. High TUBB8 expression shows unfavorable associations in ACC, KIRC and CHOL, but favorable associations in OV, LUSC and BLCA. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for TUBB8 RNA expression.
This table summarizes TUBB8 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 4. The strongest signals are observed in LUAD for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for TUBB8. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TUBB8 shows lower tumor expression in KIRC and higher tumor expression in LUAD, BLCA, UCEC, BRCA and LUSC. The LUAD box plot shows higher TUBB8 RNA expression in tumor versus normal tissue (log2 FC = +0.234, t-test p < 0.001).
This table shows molecular features associated with TUBB8 in patient tissues and cancer cell lines. In patient samples, TUBB8 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, TUBB8 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in OVARY and SOFT_TISSUE.
