TUBB8

Across TCGA pan-cancer cohorts, TUBB8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TUBB8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TUBB8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TUBB8 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

LUAD, KIRC, and BLCA are the cancer types where TUBB8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUBB8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.234	<.001	8	view →
KIRC	Male	II,III,IV	−0.132	<.001	7	view →
BLCA	All	All	+0.440	.001	6	view →
UCEC	All	All	+0.410	.003	6	view →
BRCA	All	II,III,IV	+0.304	<.001	6	view →
LUSC	All	All	+0.167	<.001	5	view →
STAD	Male	II,III,IV	+0.120	.001	5	view →
CHOL	All	All	+0.453	.027	2	view →
ESCA	All	II,III,IV	+0.155	.047	2	view →
HNSC	Male	All	+0.039	.027	2	view →
THCA	Male	All	−0.215	.025	1	view →
KIRP	All	All	−0.095	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TUBB8–LUAD

Open the LUAD breakdown →