TUBB8

Across TCGA patient cohorts, TUBB8 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB8-associated genes across cancer lineages are PI3K-p110-a, ACC1, and Notch1. Each is linked with TUBB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB8-to-partner and partner-to-TUBB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p110-a grouped by TUBB8-low versus TUBB8-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB8→partner) and Y-score (partner→TUBB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PI3K-p110-a →	+0.154	+2.824	.024	.036	3	2
UCEC	ACC1 →	+0.435	+2.820	.022	.035	3	2
UCEC	Notch1 →	+0.165	+2.820	.025	.035	3	2
UCEC	ATM →	-0.816	-3.321	<.001	.010	3	2
UCEC	eIF4E →	+0.256	+3.321	.020	.010	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.727	+3.009	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PI3K-p110-a by TUBB8 expression — LUAD

Explore this box plot interactively →