Q-omics provides the consensus-scored TUBB3 profile across patient tissues and cancer cell-line models. TUBB3 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, TUBB3 is differentially expressed in 17, with the highest sampling consensus in HNSC. Additionally, TUBB3 RNA expression shows 18,559 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, HNSC, and UVM as cancer lineages where TUBB3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TUBB3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TUBB3 survival associations across molecular data types. TUBB3 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TUBB3 RNA expression–survival associations across cancer types. High TUBB3 expression shows unfavorable associations in KIRC, UVM, MESO, CESC, ACC and BLCA. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for TUBB3 RNA expression.
This table summarizes TUBB3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 17. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for TUBB3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TUBB3 shows higher tumor expression in HNSC, LUAD, KIRP, BLCA, THCA and COAD. The HNSC box plot shows higher TUBB3 RNA expression in tumor versus normal tissue (log2 FC = +1.832, t-test p < 0.001).
This table shows molecular features associated with TUBB3 in patient tissues and cancer cell lines. In patient samples, TUBB3 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, TUBB3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and SKIN.
