TUBB3

Across TCGA patient cohorts, TUBB3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB3-associated genes across cancer lineages are p21, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with TUBB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB3-to-partner and partner-to-TUBB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by TUBB3-low versus TUBB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB3→partner) and Y-score (partner→TUBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.184	+3.584	.009	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.871	+1.926	<.001	.008	3	2
UCEC	EGFR_pY1068 →	-0.230	-2.247	.012	.001	3	1
UCEC	EGFR →	-0.133	-1.502	.023	.030	3	1
UCEC	IGFBP2 →	-0.636	-1.502	.007	.030	3	1
UCEC	JNK2 →	+0.219	+2.486	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

p21 by TUBB3 expression — UCEC

Explore this box plot interactively →