TUBB3

Across TCGA patient cohorts, TUBB3 mutation is significantly associated with the RNA expression of many other genes, with 2,148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB3-associated genes across cancer lineages are PGAM1, PRAMEF8, and RNU6-1174P. Each is linked with TUBB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TUBB3-to-partner and partner-to-TUBB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGAM1 grouped by TUBB3-low versus TUBB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB3→partner) and Y-score (partner→TUBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGAM1 →	+0.805	+2.928	<.001	<.001	3	3
READ	PRAMEF8 →	+0.032	+5.691	<.001	<.001	3	2
READ	RNU6-1174P →	+0.346	+4.672	<.001	.004	3	2
LUSC	ABLIM1 →	+0.818	+3.333	.004	.005	3	2
UCEC	FCGR1CP →	+0.359	+2.773	.001	.002	3	2
UCEC	LINC01607 →	-0.797	-3.885	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,148 associations by consensus.

PGAM1 by TUBB3 expression — UCEC

Explore this box plot interactively →