TUBB3

Across TCGA cell cohorts, TUBB3 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TUBB3-associated genes across cancer lineages are BMP10, CCDC185, and CNR2. Each is linked with TUBB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB3-to-partner and partner-to-TUBB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP10 grouped by TUBB3-low versus TUBB3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB3→partner) and Y-score (partner→TUBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	BMP10 →	+0.021	+3.263	.003	.006	3	2
SOFT_TISSUE	CCDC185 →	+0.048	+4.635	<.001	.003	3	1
SOFT_TISSUE	CNR2 →	+0.018	+4.548	<.001	.002	2	2
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	1
OESOPHAGUS	CD300LD →	+0.013	+4.906	<.001	.006	3	1
SKIN	C5orf67 →	+0.195	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

BMP10 by TUBB3 expression — OVARY

Explore this box plot interactively →