Q-omics provides the consensus-scored TSNARE1 profile across patient tissues and cancer cell-line models. TSNARE1 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, TSNARE1 is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, TSNARE1 RNA expression shows 19,111 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and KIRC as cancer lineages where TSNARE1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TSNARE1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TSNARE1 survival associations across molecular data types. TSNARE1 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (8) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TSNARE1 RNA expression–survival associations across cancer types. High TSNARE1 expression shows unfavorable associations in UVM, COAD, LIHC, THCA and KICH, but favorable associations in SCLC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify UVM as the clearest survival context for TSNARE1 RNA expression.
This table summarizes TSNARE1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for TSNARE1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TSNARE1 shows higher tumor expression in KIRC, COAD, LIHC, HNSC, STAD and CHOL. The KIRC box plot shows higher TSNARE1 RNA expression in tumor versus normal tissue (log2 FC = +0.481, t-test p < 0.001).
This table shows molecular features associated with TSNARE1 in patient tissues and cancer cell lines. In patient samples, TSNARE1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, TSNARE1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Leukemia.
