TSNARE1

Across TCGA cell cohorts, TSNARE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,013 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TSNARE1-associated GO terms across cancer lineages are Positive regulation of sphingolipid biosynthetic process, Transcription pausing by RNA polymerase II, and Positive regulation of ceramide biosynthetic process. Each is linked with TSNARE1 in more than 10 cancer types. Because this analysis shows association rather than direction, both TSNARE1-to-partner and partner-to-TSNARE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of sphingolipid biosynthetic process grouped by TSNARE1-low versus TSNARE1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSNARE1→partner) and Y-score (partner→TSNARE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of sphingolipid biosynthetic process →	+0.118	+1.041	<.001	.003	3	11
LUNG_NSCLC_LUSC	Transcription pausing by RNA polymerase II →	+0.132	+1.344	.007	<.001	3	11
LUNG_SCLC	Positive regulation of ceramide biosynthetic process →	+0.118	+1.041	<.001	.003	3	11
SOFT_TISSUE	Cilium movement involved in cell motility →	-0.072	-0.545	.003	.008	2	11
URINARY_TRACT	Cellular response to salt →	+0.157	+0.922	<.001	.005	2	11
URINARY_TRACT	Response to sodium arsenite →	+0.209	+0.816	<.001	.007	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,013 associations by consensus.

Positive regulation of sphingolipid biosynthetic process by TSNARE1 expression — LUNG_SCLC

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