transmembrane protein with metallophosphoesterase domainGenealiases: []
Q-omics provides the consensus-scored TMPPE profile across patient tissues and cancer cell-line models. TMPPE expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, TMPPE is differentially expressed in 11, with the highest sampling consensus in HNSC. Additionally, TMPPE RNA expression shows 19,769 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight ACC, HNSC, and THYM as cancer lineages where TMPPE shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TMPPE — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TMPPE survival associations across molecular data types. TMPPE RNA expression shows survival associations in the most cancer types (24), followed by mutation status (4) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TMPPE RNA expression–survival associations across cancer types. High TMPPE expression shows unfavorable associations in ACC and BLCA, but favorable associations in UVM, HNSC, KIRC and UCS. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for TMPPE RNA expression.
This table summarizes TMPPE tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 4. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for TMPPE. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TMPPE shows lower tumor expression in KIRC and higher tumor expression in HNSC, UCEC, STAD, BLCA and BRCA. The HNSC box plot shows higher TMPPE RNA expression in tumor versus normal tissue (log2 FC = +0.630, t-test p < 0.001).
This table shows molecular features associated with TMPPE in patient tissues and cancer cell lines. In patient samples, TMPPE shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, TMPPE RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and UPPER_AERODIGESTIVE_TRACT.
