Across TCGA patient cohorts, TMPPE mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPPE-associated genes across cancer lineages are eEF2, EGFR_pY1173, and PCNA. Each is linked with TMPPE in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPPE-to-partner and partner-to-TMPPE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPPE→partner) and Y-score (partner→TMPPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.589	+3.169	.002	.020	3	1
UCEC	EGFR_pY1173 →	+0.103	+3.196	.018	.010	3	1
UCEC	PCNA →	+0.457	+3.000	<.001	.036	3	1
UCEC	TIGAR →	+0.215	+3.196	.010	.010	3	1
UCEC	c-Met_pY1235 →	+0.086	+2.817	.035	.036	3	1
UCEC	Raptor →	-0.184	-3.169	.027	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

TMPPE survival (RNA) · tumor vs normal (RNA) · all TMPPE data types