Across TCGA patient cohorts, TMPPE mutation is significantly associated with the RNA expression of many other genes, with 521 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPPE-associated genes across cancer lineages are TUBB1P2, RAB8B, and GAPDHP17. Each is linked with TMPPE in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPPE-to-partner and partner-to-TMPPE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPPE→partner) and Y-score (partner→TMPPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TUBB1P2 →	+0.030	+3.646	<.001	.009	3	2
UCEC	RAB8B →	+0.739	+3.470	.001	.003	3	2
SKCM	GAPDHP17 →	+0.017	+3.993	<.001	.008	3	2
UCEC	PLEKHA1 →	+0.728	+3.480	.004	.002	3	2
UCEC	LIN54 →	+0.586	+3.202	.006	.009	3	2
UCEC	XACT →	+0.341	+3.299	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 521 associations by consensus.

Exploration

TMPPE survival (RNA) · tumor vs normal (RNA) · all TMPPE data types