Across TCGA cell cohorts, TMPPE mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMPPE-associated genes across cancer lineages are TAFA1 and CLEC2A. Each is linked with TMPPE in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPPE-to-partner and partner-to-TMPPE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPPE→partner) and Y-score (partner→TMPPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAFA1 →	+0.402	+4.273	<.001	.006	3	1
BREAST	CLEC2A →	+0.171	+4.199	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration

TMPPE survival (RNA) · tumor vs normal (RNA) · all TMPPE data types