Across TCGA pan-cancer cohorts, TMPPE mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMPPE data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TMPPE mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TMPPE expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where TMPPE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	0.989	0.133	.020	19	view →
LUAD	OS	Tertile	All	0.958	1.000	.024	7	view →
GBM	DFS	Tertile	All	0.486	0.234	.005	6	view →
HNSC	DFS	Quartile	III,IV	0.406	0.949	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TMPPE tumor-vs-normal RNA expression · all TMPPE data types