testis development related proteinGenealiases: C8orf42 · Inm01 · TDRP1 · TDRP2
Q-omics provides the consensus-scored TDRP profile across patient tissues and cancer cell-line models. TDRP expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, TDRP is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, TDRP RNA expression shows 19,327 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UCEC, HNSC, and UVM as cancer lineages where TDRP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TDRP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TDRP survival associations across molecular data types. TDRP RNA expression shows survival associations in the most cancer types (24), followed by mutation status (2) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TDRP RNA expression–survival associations across cancer types. High TDRP expression shows unfavorable associations in UCEC and STAD, but favorable associations in BRCA, LGG, PAAD and ESCA. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify UCEC as the clearest survival context for TDRP RNA expression.
This table summarizes TDRP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 5. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for TDRP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TDRP shows lower tumor expression in KICH, BRCA, KIRC, STAD and LUSC and higher tumor expression in HNSC. The HNSC box plot shows higher TDRP RNA expression in tumor versus normal tissue (log2 FC = +1.155, t-test p < 0.001).
This table shows molecular features associated with TDRP in patient tissues and cancer cell lines. In patient samples, TDRP shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, TDRP RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in LUNG_SCLC and LARGE_INTESTINE.
