TDRP

Across TCGA pan-cancer cohorts, TDRP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TDRP data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TDRP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TDRP expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and GBM are the cancer types where TDRP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.778	0.373	.001	37	view →
LSCC	DFS	Median	II,III,IV	0.922	0.641	.010	18	view →
GBM	DFS	Quartile	All	0.489	0.245	.006	16	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.179	.018	4	view →
PDAC	DFS	Median	IV	0.245	0.715	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TDRP–CCRCC (DFS)

Open the CCRCC breakdown →