TDRP

Across TCGA patient cohorts, TDRP mutation is significantly associated with the RNA expression of many other genes, with 409 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TDRP-associated genes across cancer lineages are RNU4-65P, RPL12P5, and H2AB3. Each is linked with TDRP in more than 1 cancer types. Because this analysis shows association rather than direction, both TDRP-to-partner and partner-to-TDRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-65P grouped by TDRP-low versus TDRP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRP→partner) and Y-score (partner→TDRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-65P →	+0.240	+3.716	<.001	.002	3	2
COAD	RPL12P5 →	+0.131	+3.942	.006	.002	3	2
SKCM	H2AB3 →	+0.109	+7.816	<.001	.008	3	1
SKCM	BTG3P1 →	+0.089	+7.816	<.001	.008	3	1
SKCM	RNU6-1211P →	+0.283	+7.816	<.001	.008	3	1
UCEC	LAMTOR1 →	+0.438	+3.354	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 409 associations by consensus.

RNU4-65P by TDRP expression — UCEC

Explore this box plot interactively →