Q-omics provides the consensus-scored SPINK1 profile across patient tissues and cancer cell-line models. SPINK1 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, SPINK1 is differentially expressed in 10, with the highest sampling consensus in HNSC. Additionally, SPINK1 RNA expression shows 13,877 significant protein co-abundance associations, with the highest sampling consensus in PDAC. Together, these results highlight HNSC, and PDAC as cancer lineages where SPINK1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SPINK1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SPINK1 survival associations across molecular data types. SPINK1 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (1) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SPINK1 RNA expression–survival associations across cancer types. High SPINK1 expression shows unfavorable associations in HNSC, KIRP, UVM, KIRC and THCA, but favorable associations in BLCA. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for SPINK1 RNA expression.
This table summarizes SPINK1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 4. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for SPINK1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SPINK1 shows lower tumor expression in KIRC and KIRP and higher tumor expression in HNSC, LUAD, CHOL and LIHC. The HNSC box plot shows higher SPINK1 RNA expression in tumor versus normal tissue (log2 FC = +0.645, t-test p < 0.001).
This table shows molecular features associated with SPINK1 in patient tissues and cancer cell lines. In patient samples, SPINK1 shows the broadest associations at the RNA and protein expression levels, with PDAC recurring as the lineage with the largest associated feature set. In cancer cell lines, SPINK1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in LUNG_SCLC and LARGE_INTESTINE.
