SPINK1

Across TCGA cell cohorts, SPINK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,884 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPINK1-associated GO terms across cancer lineages are Retinoid metabolic process, Fatty acid beta-oxidation using acyl-CoA oxidase, and Cellular response to steroid hormone stimulus. Each is linked with SPINK1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPINK1-to-partner and partner-to-SPINK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Retinoid metabolic process grouped by SPINK1-low versus SPINK1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK1→partner) and Y-score (partner→SPINK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Retinoid metabolic process →	+0.110	+2.343	<.001	.003	3	6
KIDNEY	Fatty acid beta-oxidation using acyl-CoA oxidase →	+0.111	+1.995	.001	.004	3	6
LARGE_INTESTINE	Cellular response to steroid hormone stimulus →	+0.081	+3.707	<.001	<.001	3	6
CNS	Macroautophagy →	+0.037	+0.558	<.001	.004	3	6
LARGE_INTESTINE	Carbohydrate homeostasis →	+0.053	+2.737	.002	.003	3	6
LIVER	Regulation of cytotoxic T cell degranulation →	+1.442	+4.925	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,884 associations by consensus.

Retinoid metabolic process by SPINK1 expression — PANCREAS

Explore this box plot interactively →