SPINK1

Across TCGA patient cohorts, SPINK1 protein abundance is significantly associated with the protein abundance of many other proteins, with 6,384 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SPINK1-associated proteins across cancer lineages are CRTAP, PLAU, and PLOD1. Each is linked with SPINK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPINK1-to-partner and partner-to-SPINK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINK1 versus CRTAP in COAD, with a Pearson correlation of -0.50.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK1→partner) and Y-score (partner→SPINK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CRTAP →	-0.575	-1.324	<.001	<.001	3	3
COAD	PLAU →	-0.795	-1.325	<.001	<.001	3	3
COAD	PLOD1 →	-0.491	-1.399	<.001	<.001	3	3
COAD	RAD9A_S328 →	+0.424	+1.307	<.001	<.001	3	2
COAD	PRKCI_T412 →	-0.829	-1.165	<.001	.001	3	2
PDAC	RAB7A_S72 →	-0.998	-0.690	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,384 associations by consensus.

SPINK1 vs CRTAP — COAD

Explore this scatter interactively →