SPINK1

Across TCGA pan-cancer cohorts, SPINK1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPINK1 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SPINK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPINK1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, UCEC, and CCRCC are the cancer types where SPINK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.201	0.911	.010	12	view →
UCEC	DFS	Median	II,III,IV	0.619	1.000	.038	4	view →
CCRCC	DFS	Quartile	All	0.917	0.618	.041	2	view →
GBM	DFS	Median	All	0.711	1.000	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPINK1–LSCC (DFS)

Open the LSCC breakdown →