SPINK1

Across TCGA patient cohorts, SPINK1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,399 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SPINK1-associated genes across cancer lineages are RNF186, PLOD1, and ARSL. Each is linked with SPINK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPINK1-to-partner and partner-to-SPINK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINK1 versus RNF186 in COAD, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK1→partner) and Y-score (partner→SPINK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNF186 →	+0.827	+0.937	<.001	<.001	3	3
COAD	PLOD1 →	-0.748	-0.867	<.001	.004	3	3
UCEC	ARSL →	+2.569	+1.202	<.001	<.001	3	3
COAD	FOXRED2 →	-0.743	-0.888	.008	.003	3	2
COAD	PYGL →	-0.928	-1.046	.006	.002	3	2
COAD	RAI1 →	-0.810	-0.817	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,399 associations by consensus.

SPINK1 vs RNF186 — COAD

Explore this scatter interactively →