SPINK1

Across TCGA patient cohorts, SPINK1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,877 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SPINK1-associated proteins across cancer lineages are VCL_S795, BCAS1, and PLOD1. Each is linked with SPINK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPINK1-to-partner and partner-to-SPINK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINK1 versus VCL_S795 in BRCA, with a Pearson correlation of 0.29.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK1→partner) and Y-score (partner→SPINK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VCL_S795 →	+0.559	+1.015	<.001	<.001	3	4
LUAD	BCAS1 →	+1.120	+2.472	<.001	<.001	3	4
BRCA	PLOD1 →	+0.752	+1.243	<.001	<.001	3	4
BRCA	PLOD2 →	+0.932	+1.037	<.001	.001	3	4
PDAC	NUTF2 →	-0.496	-1.252	<.001	<.001	3	4
LSCC	CCN1 →	+0.652	+1.064	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,877 associations by consensus.

SPINK1 vs VCL_S795 — BRCA

Explore this scatter interactively →