spindlin family member 2AGenealiases: DXF34 · SPIN2 · TDRD25 · dJ323P24.1
Q-omics provides the consensus-scored SPIN2A profile across patient tissues and cancer cell-line models. SPIN2A expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, SPIN2A is differentially expressed in 10, with the highest sampling consensus in THCA. Additionally, SPIN2A RNA expression shows 18,857 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight HNSC, THCA, and UVM as cancer lineages where SPIN2A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SPIN2A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SPIN2A survival associations across molecular data types. SPIN2A RNA expression shows survival associations in the most cancer types (25), followed by mutation status (1) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SPIN2A RNA expression–survival associations across cancer types. High SPIN2A expression shows unfavorable associations in BLCA, UCEC and UVM, but favorable associations in HNSC, MESO and READ. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for SPIN2A RNA expression.
This table summarizes SPIN2A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for SPIN2A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SPIN2A shows lower tumor expression in THCA, BRCA and UCEC and higher tumor expression in HNSC, CHOL and PAAD. The THCA box plot shows higher SPIN2A RNA expression in normal versus tumor tissue (log2 FC = −0.076, t-test p < 0.001).
This table shows molecular features associated with SPIN2A in patient tissues and cancer cell lines. In patient samples, SPIN2A shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, SPIN2A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia.
