SPIN2A

Across TCGA patient cohorts, SPIN2A mutation is significantly associated with the RNA expression of many other genes, with 110 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIN2A-associated genes across cancer lineages are RDM1P1, RNA5SP411, and RNU6-1108P. Each is linked with SPIN2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIN2A-to-partner and partner-to-SPIN2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RDM1P1 grouped by SPIN2A-low versus SPIN2A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIN2A→partner) and Y-score (partner→SPIN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RDM1P1 →	+0.129	+7.816	<.001	.008	3	2
UCEC	RNA5SP411 →	+1.519	+2.978	<.001	.001	3	1
SKCM	RNU6-1108P →	+0.403	+7.816	<.001	.008	3	1
UCEC	PSMB2 →	+0.495	+3.218	.007	.009	3	1
UCEC	PIMREG →	+1.001	+3.202	.005	.009	3	1
UCEC	EMC8 →	+0.580	+3.202	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

RDM1P1 by SPIN2A expression — SKCM

Explore this box plot interactively →