SPIN2A

Across TCGA patient cohorts, SPIN2A mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIN2A-associated genes across cancer lineages are Tuberin, BRD4, and VEGFR2. Each is linked with SPIN2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIN2A-to-partner and partner-to-SPIN2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by SPIN2A-low versus SPIN2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIN2A→partner) and Y-score (partner→SPIN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.498	+2.817	.002	.036	2	1
UCEC	BRD4 →	+0.453	+2.814	.005	.036	2	1
UCEC	VEGFR2 →	+0.551	+2.820	.002	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Tuberin by SPIN2A expression — UCEC

Explore this box plot interactively →