Q-omics provides the consensus-scored SPAM1 profile across patient tissues and cancer cell-line models. SPAM1 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, SPAM1 is differentially expressed in 5, with the highest sampling consensus in KIRP. Additionally, SPAM1 RNA expression shows 5,857 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight KIRC, KIRP, and STAD as cancer lineages where SPAM1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SPAM1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SPAM1 survival associations across molecular data types. SPAM1 RNA expression shows survival associations in the most cancer types (17), followed by mutation status (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SPAM1 RNA expression–survival associations across cancer types. High SPAM1 expression shows unfavorable associations in KIRC, ACC, MESO, LUSC, KICH and LGG. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for SPAM1 RNA expression.
This table summarizes SPAM1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in KIRP for RNA.
This table ranks reproducible tumor–normal expression differences for SPAM1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SPAM1 shows lower tumor expression in KIRP, COAD, THCA and KIRC and higher tumor expression in LIHC. The KIRP box plot shows higher SPAM1 RNA expression in normal versus tumor tissue (log2 FC = −0.037, t-test p < 0.001).
This table shows molecular features associated with SPAM1 in patient tissues and cancer cell lines. In patient samples, SPAM1 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set. In cancer cell lines, SPAM1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and OVARY.
