SPAM1

Across TCGA pan-cancer cohorts, SPAM1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SPAM1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SPAM1 RNA is repressed in tumor relative to normal tissue. In most cancer types SPAM1 is over-expressed in tumor, although a few such as KIRP and COAD show the opposite, repressed pattern.

KIRP, COAD, and THCA are the cancer types where SPAM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPAM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	−0.037	<.001	6	view →
COAD	Male	II,III,IV	−0.011	.024	2	view →
THCA	All	All	−0.006	.029	2	view →
KIRC	All	All	−0.005	.012	2	view →
LIHC	All	All	+0.003	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SPAM1–KIRP

Open the KIRP breakdown →