SPAM1

Across TCGA patient cohorts, SPAM1 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAM1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, Rab25, and FASN. Each is linked with SPAM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPAM1-to-partner and partner-to-SPAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by SPAM1-low versus SPAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAM1→partner) and Y-score (partner→SPAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.463	+1.584	.006	.009	3	3
UCEC	Rab25 →	-0.333	-2.415	.002	.003	3	3
UCEC	FASN →	+0.283	+2.000	.032	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.474	+1.604	.017	.021	3	3
LUAD	p90 RSK_pT359_S363 →	-0.159	-2.321	.035	.035	3	2
LUAD	Rab11 →	-0.141	-2.321	.034	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

Acetyl-a-Tubulin-Lys40 by SPAM1 expression — UCEC

Explore this box plot interactively →