SPAM1

Across TCGA cell cohorts, SPAM1 RNA expression is significantly associated with the mutation status of many other genes, with 44 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPAM1-associated genes across cancer lineages are NUP210L, SHROOM3, and TTN. Each is linked with SPAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAM1-to-partner and partner-to-SPAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUP210L grouped by SPAM1-low versus SPAM1-high in OESOPHAGUS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAM1→partner) and Y-score (partner→SPAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NUP210L →	+4.906	+0.013	.006	<.001	3	2
SOFT_TISSUE	SHROOM3 →	+4.369	+0.019	.008	<.001	3	2
OVARY	TTN →	-1.604	-0.019	.008	.008	3	2
BLOOD_Lymphoma	CPAMD8 →	+3.342	+0.037	.008	<.001	3	2
OESOPHAGUS	RELB →	+4.906	+0.013	.006	<.001	3	1
OESOPHAGUS	PDE6B →	+4.906	+0.013	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

NUP210L by SPAM1 expression — OESOPHAGUS

Explore this box plot interactively →