SPAM1

Across TCGA cell cohorts, SPAM1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible SPAM1-associated genes across cancer lineages are FHL5, OR5B3, and KRTAP11-1. Each is linked with SPAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAM1-to-partner and partner-to-SPAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FHL5 grouped by SPAM1-low versus SPAM1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAM1→partner) and Y-score (partner→SPAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FHL5 →	+0.023	+4.643	<.001	.008	3	2
SKIN	OR5B3 →	+0.033	+4.415	<.001	.007	3	1
SKIN	KRTAP11-1 →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TECRL →	+0.026	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	MC3R →	+0.122	+4.459	.001	.001	3	1
BLOOD_Lymphoma	SLC39A12 →	+0.051	+3.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

FHL5 by SPAM1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →