SPAM1

Across TCGA patient cohorts, SPAM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,857 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPAM1-associated GO terms across cancer lineages are Telomerase RNA localization, Blastocyst development, and Receptor internalization. Each is linked with SPAM1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SPAM1-to-partner and partner-to-SPAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomerase RNA localization grouped by SPAM1-low versus SPAM1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAM1→partner) and Y-score (partner→SPAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Telomerase RNA localization →	+0.038	+0.048	<.001	<.001	3	9
ESCA	Blastocyst development →	+0.058	+0.061	<.001	.002	2	9
STAD	Receptor internalization →	+0.051	+0.070	<.001	<.001	3	8
STAD	Meiotic cell cycle →	+0.035	+0.060	<.001	.001	3	8
STAD	Regulation of mitochondrial gene expression →	+0.067	+0.091	<.001	<.001	3	8
STAD	Mitochondrial membrane organization →	+0.039	+0.037	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,857 associations by consensus.

Telomerase RNA localization by SPAM1 expression — STAD

Explore this box plot interactively →