SPAM1

Across TCGA patient cohorts, SPAM1 mutation is significantly associated with the RNA expression of many other genes, with 3,822 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAM1-associated genes across cancer lineages are MFSD12, POC1A, and PATL1. Each is linked with SPAM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPAM1-to-partner and partner-to-SPAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MFSD12 grouped by SPAM1-low versus SPAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAM1→partner) and Y-score (partner→SPAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MFSD12 →	+0.386	+2.147	.002	<.001	3	3
UCEC	POC1A →	+0.518	+3.807	.001	<.001	3	3
UCEC	PATL1 →	+0.477	+3.180	<.001	<.001	3	3
UCEC	SLC3A2 →	+0.495	+2.158	<.001	<.001	3	3
UCEC	GPRC5C →	-0.746	-1.946	.002	.009	3	3
UCEC	MUC20 →	-1.053	-2.305	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,822 associations by consensus.

MFSD12 by SPAM1 expression — UCEC

Explore this box plot interactively →