Q-omics provides the consensus-scored SPAG8 profile across patient tissues and cancer cell-line models. SPAG8 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, SPAG8 is differentially expressed in 11, with the highest sampling consensus in LUAD. Additionally, SPAG8 RNA expression shows 17,852 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight UVM, LUAD, and KIRP as cancer lineages where SPAG8 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SPAG8 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SPAG8 survival associations across molecular data types. SPAG8 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (2) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SPAG8 RNA expression–survival associations across cancer types. High SPAG8 expression shows favorable associations in UVM, BRCA, UCS, KIRP, PAAD and SKCM. The UVM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for SPAG8 RNA expression.
This table summarizes SPAG8 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 6. The strongest signals are observed in LUAD for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for SPAG8. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SPAG8 shows lower tumor expression in LUAD, LUSC, BLCA, KICH and BRCA and higher tumor expression in LIHC. The LUAD box plot shows higher SPAG8 RNA expression in normal versus tumor tissue (log2 FC = −1.558, t-test p < 0.001).
This table shows molecular features associated with SPAG8 in patient tissues and cancer cell lines. In patient samples, SPAG8 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, SPAG8 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and UPPER_AERODIGESTIVE_TRACT.
